Title |
Bruton’s Tyrosine Kinase: An Emerging Key Player in Innate Immunity
|
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Published in |
Frontiers in immunology, November 2017
|
DOI | 10.3389/fimmu.2017.01454 |
Pubmed ID | |
Authors |
Alexander N. R. Weber, Zsofia Bittner, Xiao Liu, Truong-Minh Dang, Markus Philipp Radsak, Cornelia Brunner |
Abstract |
Bruton's tyrosine kinase (BTK) was initially discovered as a critical mediator of B cell receptor signaling in the development and functioning of adaptive immunity. Growing evidence also suggests multiple roles for BTK in mononuclear cells of the innate immune system, especially in dendritic cells and macrophages. For example, BTK has been shown to function in Toll-like receptor-mediated recognition of infectious agents, cellular maturation and recruitment processes, and Fc receptor signaling. Most recently, BTK was additionally identified as a direct regulator of a key innate inflammatory machinery, the NLRP3 inflammasome. BTK has thus attracted interest not only for gaining a more thorough basic understanding of the human innate immune system but also as a target to therapeutically modulate innate immunity. We here review the latest developments on the role of BTK in mononuclear innate immune cells in mouse versus man, with specific emphasis on the sensing of infectious agents and the induction of inflammation. Therapeutic implications for modulating innate immunity and critical open questions are also discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 25% |
Japan | 1 | 13% |
France | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Scientists | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 193 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 31 | 16% |
Researcher | 28 | 15% |
Student > Bachelor | 22 | 11% |
Student > Master | 16 | 8% |
Student > Doctoral Student | 10 | 5% |
Other | 29 | 15% |
Unknown | 57 | 30% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 36 | 19% |
Immunology and Microbiology | 27 | 14% |
Medicine and Dentistry | 24 | 12% |
Agricultural and Biological Sciences | 13 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 4% |
Other | 26 | 13% |
Unknown | 59 | 31% |