Title |
Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond
|
---|---|
Published in |
Frontiers in immunology, November 2017
|
DOI | 10.3389/fimmu.2017.01530 |
Pubmed ID | |
Authors |
Cecília Jacques Gonçalves de Almeida |
Abstract |
Caveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1. Notwithstanding, Cav-2 has unpredictable activities, opposing Cav-1 in the regulation of some cellular processes. While the major roles of Cav-1 as a modulator of cell signaling in inflammatory processes and in immune responses have been extensively discussed elsewhere, the aim of this review is to focus on data revealing the distinct activity of Cav-1 and Cav-2, which suggest that these proteins act antagonistically to fine-tune a variety of cellular processes relevant to inflammation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 70 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 12 | 17% |
Student > Bachelor | 12 | 17% |
Student > Ph. D. Student | 11 | 16% |
Researcher | 6 | 9% |
Other | 5 | 7% |
Other | 6 | 9% |
Unknown | 18 | 26% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 16 | 23% |
Agricultural and Biological Sciences | 9 | 13% |
Medicine and Dentistry | 9 | 13% |
Neuroscience | 5 | 7% |
Immunology and Microbiology | 3 | 4% |
Other | 10 | 14% |
Unknown | 18 | 26% |