Title |
Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention
|
---|---|
Published in |
Frontiers in immunology, November 2017
|
DOI | 10.3389/fimmu.2017.01674 |
Pubmed ID | |
Authors |
Sai-Long Zhang, Shu-Na Wang, Chao-Yu Miao |
Abstract |
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with chronic and recurrent characteristics caused by multiple reasons. Although the pathogenic factors have not been clarified yet, recent studies have demonstrated that intestinal microbiota plays a major role in UC, especially in the immune system. This review focuses on the description of several major microbiota communities that affect UC and their interactions with the host. In this review, eight kinds of microbiota that are highly related to IBD, including Faecalibacterium prausnitzii, Clostridium clusters IV and XIVa, Bacteroides, Roseburia species, Eubacterium rectale, Escherichia coli, Fusobacterium, and Candida albicans are demonstrated on the changes in amount and roles in the onset and progression of IBD. In addition, potential therapeutic targets for UC involved in the regulation of microbiota, including NLRPs, vitamin D receptor as well as secreted proteins, are discussed in this review. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 33% |
Georgia | 1 | 6% |
Ireland | 1 | 6% |
Unknown | 10 | 56% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 12 | 67% |
Scientists | 3 | 17% |
Practitioners (doctors, other healthcare professionals) | 3 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 160 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 14% |
Researcher | 21 | 13% |
Student > Master | 16 | 10% |
Student > Bachelor | 13 | 8% |
Student > Postgraduate | 12 | 8% |
Other | 30 | 19% |
Unknown | 45 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 18% |
Immunology and Microbiology | 23 | 14% |
Biochemistry, Genetics and Molecular Biology | 18 | 11% |
Agricultural and Biological Sciences | 14 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Other | 17 | 11% |
Unknown | 55 | 34% |