Title |
Macrophage–Microbe Interactions: Lessons from the Zebrafish Model
|
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Published in |
Frontiers in immunology, December 2017
|
DOI | 10.3389/fimmu.2017.01703 |
Pubmed ID | |
Authors |
Nagisa Yoshida, Eva-Maria Frickel, Serge Mostowy |
Abstract |
Macrophages provide front line defense against infections. The study of macrophage-microbe interplay is thus crucial for understanding pathogenesis and infection control. Zebrafish (Danio rerio) larvae provide a unique platform to study macrophage-microbe interactions in vivo, from the level of the single cell to the whole organism. Studies using zebrafish allow non-invasive, real-time visualization of macrophage recruitment and phagocytosis. Furthermore, the chemical and genetic tractability of zebrafish has been central to decipher the complex role of macrophages during infection. Here, we discuss the latest developments using zebrafish models of bacterial and fungal infection. We also review novel aspects of macrophage biology revealed by zebrafish, which can potentiate development of new therapeutic strategies for humans. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 4 | 29% |
United States | 2 | 14% |
Australia | 1 | 7% |
Netherlands | 1 | 7% |
Germany | 1 | 7% |
France | 1 | 7% |
Unknown | 4 | 29% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 10 | 71% |
Scientists | 4 | 29% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 19% |
Student > Master | 9 | 15% |
Researcher | 6 | 10% |
Student > Doctoral Student | 6 | 10% |
Student > Bachelor | 4 | 6% |
Other | 11 | 18% |
Unknown | 14 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 23% |
Immunology and Microbiology | 14 | 23% |
Biochemistry, Genetics and Molecular Biology | 10 | 16% |
Medicine and Dentistry | 2 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 5 | 8% |
Unknown | 16 | 26% |