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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Regulation of Fn14 Receptor and NF-κB Underlies Inflammation in Meniere’s Disease
|
|---|---|
| Published in |
Frontiers in immunology, December 2017
|
| DOI | 10.3389/fimmu.2017.01739 |
| Pubmed ID | |
| Authors |
Lidia Frejo, Teresa Requena, Satoshi Okawa, Alvaro Gallego-Martinez, Manuel Martinez-Bueno, Ismael Aran, Angel Batuecas-Caletrio, Jesus Benitez-Rosario, Juan M. Espinosa-Sanchez, Jesus José Fraile-Rodrigo, Ana María García-Arumi, Rocío González-Aguado, Pedro Marques, Eduardo Martin-Sanz, Nicolas Perez-Fernandez, Paz Pérez-Vázquez, Herminio Perez-Garrigues, Sofía Santos-Perez, Andres Soto-Varela, Maria C. Tapia, Gabriel Trinidad-Ruiz, Antonio del Sol, Marta E. Alarcon Riquelme, Jose A. Lopez-Escamez |
| Abstract |
Meniere's disease (MD) is a rare disorder characterized by episodic vertigo, sensorineural hearing loss, tinnitus, and aural fullness. It is associated with a fluid imbalance between the secretion of endolymph in the cochlear duct and its reabsorption into the subarachnoid space, leading to an accumulation of endolymph in the inner ear. Epidemiological evidence, including familial aggregation, indicates a genetic contribution and a consistent association with autoimmune diseases (AD). We conducted a case-control study in two phases using an immune genotyping array in a total of 420 patients with bilateral MD and 1,630 controls. We have identified the first locus, at 6p21.33, suggesting an association with bilateral MD [meta-analysis leading signal rs4947296, OR = 2.089 (1.661-2.627); p = 1.39 × 10-09]. Gene expression profiles of homozygous genotype-selected peripheral blood mononuclear cells (PBMCs) demonstrated that this region is a trans-expression quantitative trait locus (eQTL) in PBMCs. Signaling analysis predicted several tumor necrosis factor-related pathways, the TWEAK/Fn14 pathway being the top candidate (p = 2.42 × 10-11). This pathway is involved in the modulation of inflammation in several human AD, including multiple sclerosis, systemic lupus erythematosus, or rheumatoid arthritis. In vitro studies with genotype-selected lymphoblastoid cells from patients with MD suggest that this trans-eQTL may regulate cellular proliferation in lymphoid cells through the TWEAK/Fn14 pathway by increasing the translation of NF-κB. Taken together; these findings suggest that the carriers of the risk genotype may develop an NF-κB-mediated inflammatory response in MD. |
X Demographics
The data shown below were collected from the profiles of 29 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 8 | 28% |
| United Kingdom | 2 | 7% |
| Ecuador | 1 | 3% |
| Switzerland | 1 | 3% |
| Unknown | 17 | 59% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 69% |
| Scientists | 7 | 24% |
| Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 60 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 12% |
| Researcher | 5 | 8% |
| Professor > Associate Professor | 5 | 8% |
| Other | 4 | 7% |
| Librarian | 3 | 5% |
| Other | 14 | 23% |
| Unknown | 22 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 35% |
| Agricultural and Biological Sciences | 4 | 7% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Chemistry | 2 | 3% |
| Immunology and Microbiology | 2 | 3% |
| Other | 7 | 12% |
| Unknown | 22 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2021.
All research outputs
#1,704,301
of 25,382,440 outputs
Outputs from Frontiers in immunology
#1,535
of 31,537 outputs
Outputs of similar age
#37,614
of 443,420 outputs
Outputs of similar age from Frontiers in immunology
#42
of 589 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,537 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,420 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 589 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.