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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Tolerance through Education: How Tolerogenic Dendritic Cells Shape Immunity
|
|---|---|
| Published in |
Frontiers in immunology, December 2017
|
| DOI | 10.3389/fimmu.2017.01764 |
| Pubmed ID | |
| Authors |
Matthias P. Domogalla, Patricia V. Rostan, Verena K. Raker, Kerstin Steinbrink |
| Abstract |
Dendritic cells (DCs) are central players in the initiation and control of responses, regulating the balance between tolerance and immunity. Tolerogenic DCs are essential in the maintenance of central and peripheral tolerance by induction of clonal T cell deletion and T cell anergy, inhibition of memory and effector T cell responses, and generation and activation of regulatory T cells. Therefore, tolerogenic DCs are promising candidates for specific cellular therapy of allergic and autoimmune diseases and for treatment of transplant rejection. Studies performed in rodents have demonstrated the efficacy and feasibility of tolerogenic DCs for tolerance induction in various inflammatory diseases. In the last years, numerous protocols for the generation of human monocyte-derived tolerogenic DCs have been established and some first phase I trials have been conducted in patients suffering from autoimmune disorders, demonstrating the safety and efficiency of this cell-based immunotherapy. This review gives an overview about methods and protocols for the generation of human tolerogenic DCs and their mechanisms of tolerance induction with the focus on interleukin-10-modulated DCs. In addition, we will discuss the prerequisites for optimal clinical grade tolerogenic DC subsets and results of clinical trials with tolerogenic DCs in autoimmune diseases. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 3 | 43% |
| United Kingdom | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 345 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 345 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 65 | 19% |
| Student > Bachelor | 49 | 14% |
| Student > Master | 43 | 12% |
| Researcher | 38 | 11% |
| Student > Doctoral Student | 19 | 6% |
| Other | 40 | 12% |
| Unknown | 91 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 95 | 28% |
| Biochemistry, Genetics and Molecular Biology | 51 | 15% |
| Medicine and Dentistry | 25 | 7% |
| Agricultural and Biological Sciences | 20 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 3% |
| Other | 33 | 10% |
| Unknown | 110 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2024.
All research outputs
#3,255,241
of 25,382,440 outputs
Outputs from Frontiers in immunology
#3,502
of 31,537 outputs
Outputs of similar age
#67,862
of 445,007 outputs
Outputs of similar age from Frontiers in immunology
#94
of 596 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,537 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,007 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 596 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.