You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?
|
|---|---|
| Published in |
Frontiers in immunology, January 2018
|
| DOI | 10.3389/fimmu.2017.01960 |
| Pubmed ID | |
| Authors |
Tamas Fulop, Anis Larbi, Gilles Dupuis, Aurélie Le Page, Eric H. Frost, Alan A. Cohen, Jacek M. Witkowski, Claudio Franceschi |
| Abstract |
The immune system is the most important protective physiological system of the organism. It has many connections with other systems and is, in fact, often considered as part of the larger neuro-endocrine-immune axis. Most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflamm-aging. Together, immunosenescence and inflamm-aging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of immune-gerontologists have challenged this negative interpretation of immunosenescence with respect to its significance in aging-related alterations of the immune system. If one considers these changes from an evolutionary perspective, they can be viewed preferably as adaptive or remodeling rather than solely detrimental. Whereas it is conceivable that global immune changes may lead to various diseases, it is also obvious that these changes may be needed for extended survival/longevity. Recent cumulative data suggest that, without the existence of the immunosenescence/inflamm-aging duo (representing two sides of the same phenomenon), human longevity would be greatly shortened. This review summarizes recent data on the dynamic reassessment of immune changes with aging. Accordingly, attempts to intervene on the aging immune system by targeting its rejuvenation, it may be more suitable to aim to maintain general homeostasis and function by appropriately improving immune-inflammatory-functions. |
X Demographics
The data shown below were collected from the profiles of 73 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | 19% |
| United Kingdom | 7 | 10% |
| Australia | 4 | 5% |
| Spain | 4 | 5% |
| Canada | 3 | 4% |
| Sweden | 2 | 3% |
| Ireland | 2 | 3% |
| Argentina | 1 | 1% |
| South Africa | 1 | 1% |
| Other | 8 | 11% |
| Unknown | 27 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 45 | 62% |
| Scientists | 21 | 29% |
| Practitioners (doctors, other healthcare professionals) | 5 | 7% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 940 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 940 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 136 | 14% |
| Student > Master | 122 | 13% |
| Student > Bachelor | 119 | 13% |
| Researcher | 102 | 11% |
| Student > Doctoral Student | 38 | 4% |
| Other | 135 | 14% |
| Unknown | 288 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 152 | 16% |
| Biochemistry, Genetics and Molecular Biology | 142 | 15% |
| Immunology and Microbiology | 82 | 9% |
| Agricultural and Biological Sciences | 71 | 8% |
| Neuroscience | 38 | 4% |
| Other | 118 | 13% |
| Unknown | 337 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 146. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2024.
All research outputs
#285,131
of 25,547,324 outputs
Outputs from Frontiers in immunology
#296
of 31,950 outputs
Outputs of similar age
#6,538
of 452,233 outputs
Outputs of similar age from Frontiers in immunology
#3
of 615 outputs
Altmetric has tracked 25,547,324 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,950 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 452,233 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 615 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.