Title |
Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment
|
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Published in |
Frontiers in immunology, January 2018
|
DOI | 10.3389/fimmu.2018.00040 |
Pubmed ID | |
Authors |
Sundary Sormendi, Ben Wielockx |
Abstract |
Low oxygen tension or hypoxia is a determining factor in the course of many different processes in animals, including when tissue expansion and cellular metabolism result in high oxygen demands that exceed its supply. This is mainly happening when cells actively proliferate and the proliferating mass becomes distant from the blood vessels, such as in growing tumors. Metabolic alterations in response to hypoxia can be triggered in a direct manner, such as the switch from oxidative phosphorylation to glycolysis or inhibition of fatty acid desaturation. However, as the modulated action of hypoxia-inducible factors or the oxygen sensors (prolyl hydroxylase domain-containing enzymes) can also lead to changes in enzyme expression, these metabolic changes can also be indirect. With this review, we want to summarize our current knowledge of the hypoxia-induced changes in metabolism during cancer development, how they are affected in the tumor cells and in the cells of the microenvironment, most prominently in immune cells. |
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Geographical breakdown
Country | Count | As % |
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Venezuela, Bolivarian Republic of | 1 | 25% |
United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 115 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 31 | 27% |
Student > Master | 12 | 10% |
Researcher | 9 | 8% |
Student > Bachelor | 7 | 6% |
Other | 7 | 6% |
Other | 16 | 14% |
Unknown | 33 | 29% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 8 | 7% |
Medicine and Dentistry | 8 | 7% |
Agricultural and Biological Sciences | 7 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Other | 12 | 10% |
Unknown | 42 | 37% |