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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Complement System in Dialysis: A Forgotten Story?
|
|---|---|
| Published in |
Frontiers in immunology, January 2018
|
| DOI | 10.3389/fimmu.2018.00071 |
| Pubmed ID | |
| Authors |
Felix Poppelaars, Bernardo Faria, Mariana Gaya da Costa, Casper F. M. Franssen, Willem J. van Son, Stefan P. Berger, Mohamed R. Daha, Marc A. Seelen |
| Abstract |
Significant advances have lead to a greater understanding of the role of the complement system within nephrology. The success of the first clinically approved complement inhibitor has created renewed appreciation of complement-targeting therapeutics. Several clinical trials are currently underway to evaluate the therapeutic potential of complement inhibition in renal diseases and kidney transplantation. Although, complement has been known to be activated during dialysis for over four decades, this area of research has been neglected in recent years. Despite significant progress in biocompatibility of hemodialysis (HD) membranes and peritoneal dialysis (PD) fluids, complement activation remains an undesired effect and relevant issue. Short-term effects of complement activation include promoting inflammation and coagulation. In addition, long-term complications of dialysis, such as infection, fibrosis and cardiovascular events, are linked to the complement system. These results suggest that interventions targeting the complement system in dialysis could improve biocompatibility, dialysis efficacy, and long-term outcome. Combined with the clinical availability to safely target complement in patients, the question is not if we should inhibit complement in dialysis, but when and how. The purpose of this review is to summarize previous findings and provide a comprehensive overview of the role of the complement system in both HD and PD. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 9% |
| Brazil | 2 | 9% |
| United Kingdom | 2 | 9% |
| India | 1 | 4% |
| Netherlands | 1 | 4% |
| Greece | 1 | 4% |
| Egypt | 1 | 4% |
| Switzerland | 1 | 4% |
| Mexico | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 11 | 48% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 74% |
| Scientists | 5 | 22% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 120 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 15% |
| Researcher | 15 | 13% |
| Student > Bachelor | 11 | 9% |
| Student > Master | 11 | 9% |
| Other | 10 | 8% |
| Other | 16 | 13% |
| Unknown | 39 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 41 | 34% |
| Biochemistry, Genetics and Molecular Biology | 8 | 7% |
| Immunology and Microbiology | 6 | 5% |
| Nursing and Health Professions | 4 | 3% |
| Engineering | 4 | 3% |
| Other | 14 | 12% |
| Unknown | 43 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2023.
All research outputs
#1,456,613
of 25,808,886 outputs
Outputs from Frontiers in immunology
#1,283
of 32,415 outputs
Outputs of similar age
#33,538
of 453,206 outputs
Outputs of similar age from Frontiers in immunology
#37
of 650 outputs
Altmetric has tracked 25,808,886 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,415 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 453,206 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 650 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.