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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Inhibition of Osteoblast Function by Brucella abortus is Reversed by Dehydroepiandrosterone and Involves ERK1/2 and Estrogen Receptor
|
|---|---|
| Published in |
Frontiers in immunology, January 2018
|
| DOI | 10.3389/fimmu.2018.00088 |
| Pubmed ID | |
| Authors |
María Virginia Gentilini, Ayelén Ivana Pesce Viglietti, Paula Constanza Arriola Benitez, Andrea Elena Iglesias Molli, Gloria Edith Cerrone, Guillermo Hernán Giambartolomei, María Victoria Delpino |
| Abstract |
Brucella abortus induces an inflammatory response that stimulates the endocrine system resulting in the secretion of cortisol and dehydroepiandrosterone (DHEA). Osteoarticular brucellosis is the most common presentation of the active disease in humans, and we have previously demonstrated thatB. abortusinfection inhibits osteoblast function. We aimed to evaluate the role of cortisol and DHEA on osteoblast duringB. abortusinfection.B. abortusinfection induces apoptosis and inhibits osteoblast function. DHEA treatment reversed the effect ofB. abortusinfection on osteoblast by increasing their proliferation, inhibiting osteoblast apoptosis, and reversing the inhibitory effect ofB. abortuson osteoblast differentiation and function. By contrast, cortisol increased the effect ofB. abortusinfection. Cortisol regulates target genes by binding to the glucocorticoid receptor (GR).B. abortusinfection inhibited GRα expression. Cell responses to cortisol not only depend on GR expression but also on its intracellular bioavailability, that is, dependent on the activity of the isoenzymes 11β-hydroxysteroid dehydrogenase (HSD) type-1, 11β-HSD2 (which convert cortisone to cortisol andvice versa, respectively). Alterations in the expression of these isoenzymes in bone cells are associated with bone loss.B. abortusinfection increased 11β-HSD1 expression but had no effect on 11β-HSD2. DHEA reversed the inhibitory effect induced byB. abortusinfection on osteoblast matrix deposition in an estrogen receptor- and ERK1/2-dependent manner. We conclude that DHEA intervention improves osteoblast function duringB. abortusinfection making it a potential candidate to ameliorate the osteoarticular symptoms of brucellosis. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 26% |
| Student > Master | 2 | 11% |
| Researcher | 2 | 11% |
| Professor | 2 | 11% |
| Student > Doctoral Student | 1 | 5% |
| Other | 2 | 11% |
| Unknown | 5 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 16% |
| Veterinary Science and Veterinary Medicine | 2 | 11% |
| Biochemistry, Genetics and Molecular Biology | 2 | 11% |
| Medicine and Dentistry | 2 | 11% |
| Nursing and Health Professions | 1 | 5% |
| Other | 4 | 21% |
| Unknown | 5 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2018.
All research outputs
#19,951,180
of 25,382,440 outputs
Outputs from Frontiers in immunology
#22,585
of 31,537 outputs
Outputs of similar age
#325,392
of 449,669 outputs
Outputs of similar age from Frontiers in immunology
#500
of 644 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,537 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,669 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 644 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.