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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation
|
|---|---|
| Published in |
Frontiers in immunology, February 2018
|
| DOI | 10.3389/fimmu.2018.00141 |
| Pubmed ID | |
| Authors |
Niamh C. Williams, Luke A. J. O’Neill |
| Abstract |
Metabolism in immune cells is no longer thought of as merely a process for adenosine triphosphate (ATP) production, biosynthesis, and catabolism. The reprogramming of metabolic pathways upon activation is also for the production of metabolites that can act as immune signaling molecules. Activated dendritic cells (DCs) and macrophages have an altered Krebs cycle, one consequence of which is the accumulation of both citrate and succinate. Citrate is exported from the mitochondriaviathe mitochondrial citrate- carrier. Cytosolic metabolism of citrate to acetyl-coenzyme A (acetyl-CoA) is important for both fatty-acid synthesis and protein acetylation, both of which have been linked to macrophage and DC activation. Citrate-derived itaconate has a direct antibacterial effect and also has been shown to act as an anti-inflammatory agent, inhibiting succinate dehydrogenase. These findings identify citrate as an important metabolite for macrophage and DC effector function. |
X Demographics
The data shown below were collected from the profiles of 49 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 14% |
| United Kingdom | 5 | 10% |
| Spain | 4 | 8% |
| Ireland | 3 | 6% |
| Canada | 2 | 4% |
| Switzerland | 2 | 4% |
| Kuwait | 1 | 2% |
| Sweden | 1 | 2% |
| Mexico | 1 | 2% |
| Other | 6 | 12% |
| Unknown | 17 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 33 | 67% |
| Scientists | 14 | 29% |
| Practitioners (doctors, other healthcare professionals) | 1 | 2% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 561 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 561 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 124 | 22% |
| Student > Bachelor | 67 | 12% |
| Researcher | 52 | 9% |
| Student > Master | 49 | 9% |
| Student > Doctoral Student | 30 | 5% |
| Other | 70 | 12% |
| Unknown | 169 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 141 | 25% |
| Immunology and Microbiology | 68 | 12% |
| Agricultural and Biological Sciences | 44 | 8% |
| Medicine and Dentistry | 38 | 7% |
| Chemistry | 15 | 3% |
| Other | 66 | 12% |
| Unknown | 189 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 December 2023.
All research outputs
#1,300,438
of 25,784,004 outputs
Outputs from Frontiers in immunology
#1,143
of 32,391 outputs
Outputs of similar age
#30,047
of 448,640 outputs
Outputs of similar age from Frontiers in immunology
#28
of 644 outputs
Altmetric has tracked 25,784,004 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,391 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 448,640 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 644 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.