Title |
Metabolic Modulation in Macrophage Effector Function
|
---|---|
Published in |
Frontiers in immunology, February 2018
|
DOI | 10.3389/fimmu.2018.00270 |
Pubmed ID | |
Authors |
Ciana Diskin, Eva M. Pålsson-McDermott |
Abstract |
Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic pathways generating energy and biosynthetic precursors required for growth and general cellular maintenance. However, growing literature provides evidence of a much broader role for metabolic reactions and processes in controlling immunological effector functions. Much of this research into immunometabolism has focused on macrophages, cells that are central in pro- as well as anti-inflammatory responses-responses that in turn are a direct result of metabolic reprogramming. As we learn more about the precise role of metabolic pathways and pathway intermediates in immune function, a novel opportunity to target immunometabolism therapeutically has emerged. Here, we review the current understanding of the regulation of macrophage function through metabolic remodeling. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 21% |
Spain | 2 | 11% |
Benin | 1 | 5% |
France | 1 | 5% |
Ireland | 1 | 5% |
Singapore | 1 | 5% |
Italy | 1 | 5% |
Canada | 1 | 5% |
Switzerland | 1 | 5% |
Other | 0 | 0% |
Unknown | 6 | 32% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 11 | 58% |
Scientists | 8 | 42% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 357 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 83 | 23% |
Student > Master | 47 | 13% |
Student > Bachelor | 45 | 13% |
Researcher | 43 | 12% |
Student > Doctoral Student | 27 | 8% |
Other | 35 | 10% |
Unknown | 77 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 83 | 23% |
Biochemistry, Genetics and Molecular Biology | 69 | 19% |
Agricultural and Biological Sciences | 34 | 10% |
Medicine and Dentistry | 33 | 9% |
Neuroscience | 7 | 2% |
Other | 40 | 11% |
Unknown | 91 | 25% |