Title |
PIRCHE-II Is Related to Graft Failure after Kidney Transplantation
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Published in |
Frontiers in immunology, March 2018
|
DOI | 10.3389/fimmu.2018.00321 |
Pubmed ID | |
Authors |
Kirsten Geneugelijk, Matthias Niemann, Julia Drylewicz, Arjan D van Zuilen, Irma Joosten, Wil A Allebes, Arnold van der Meer, Luuk B Hilbrands, Marije C Baas, C Erik Hack, Franka E van Reekum, Marianne C Verhaar, Elena G Kamburova, Michiel L Bots, Marc A J Seelen, Jan Stephan Sanders, Bouke G Hepkema, Annechien J Lambeck, Laura B Bungener, Caroline Roozendaal, Marcel G J Tilanus, Joris Vanderlocht, Christien E Voorter, Lotte Wieten, Elly M van Duijnhoven, Mariëlle Gelens, Maarten H L Christiaans, Frans J van Ittersum, Azam Nurmohamed, Junior N M Lardy, Wendy Swelsen, Karlijn A van der Pant, Neelke C van der Weerd, Ineke J M Ten Berge, Fréderike J Bemelman, Andries Hoitsma, Paul J M van der Boog, Johan W de Fijter, Michiel G H Betjes, Sebastiaan Heidt, Dave L Roelen, Frans H Claas, Henny G Otten, Eric Spierings |
Abstract |
Individual HLA mismatches may differentially impact graft survival after kidney transplantation. Therefore, there is a need for a reliable tool to define permissible HLA mismatches in kidney transplantation. We previously demonstrated that donor-derived Predicted Indirectly ReCognizable HLA Epitopes presented by recipient HLA class II (PIRCHE-II) play a role in de novo donor-specific HLA antibodies formation after kidney transplantation. In the present Dutch multi-center study, we evaluated the possible association between PIRCHE-II and kidney graft failure in 2,918 donor-recipient couples that were transplanted between 1995 and 2005. For these donors-recipients couples, PIRCHE-II numbers were related to graft survival in univariate and multivariable analyses. Adjusted for confounders, the natural logarithm of PIRCHE-II was associated with a higher risk for graft failure [hazard ratio (HR): 1.13, 95% CI: 1.04-1.23, p = 0.003]. When analyzing a subgroup of patients who had their first transplantation, the HR of graft failure for ln(PIRCHE-II) was higher compared with the overall cohort (HR: 1.22, 95% CI: 1.10-1.34, p < 0.001). PIRCHE-II demonstrated both early and late effects on graft failure in this subgroup. These data suggest that the PIRCHE-II may impact graft survival after kidney transplantation. Inclusion of PIRCHE-II in donor-selection criteria may eventually lead to an improved kidney graft survival. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 50% |
Israel | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 96 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 9 | 9% |
Student > Master | 8 | 8% |
Researcher | 7 | 7% |
Student > Bachelor | 6 | 6% |
Student > Doctoral Student | 5 | 5% |
Other | 17 | 18% |
Unknown | 44 | 46% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 22% |
Immunology and Microbiology | 10 | 10% |
Agricultural and Biological Sciences | 5 | 5% |
Unspecified | 3 | 3% |
Biochemistry, Genetics and Molecular Biology | 3 | 3% |
Other | 8 | 8% |
Unknown | 46 | 48% |