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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes—Activation and Age-Related Effects
|
|---|---|
| Published in |
Frontiers in immunology, March 2018
|
| DOI | 10.3389/fimmu.2018.00405 |
| Pubmed ID | |
| Authors |
Srikant Rangaraju, Syed Ali Raza, Noel Xiang’An Li, Ranjita Betarbet, Eric B. Dammer, Duc Duong, James J. Lah, Nicholas T. Seyfried, Allan I. Levey |
| Abstract |
In the central nervous system (CNS), microglia are innate immune mononuclear phagocytes (CNS MPs) that can phagocytose infectious particles, apoptotic cells, neurons, and pathological protein aggregates, such as Aβ in Alzheimer's disease (AD). While CD11b+CD45lowmicroglia account for the majority of CNS MPs, a small population of CD11b+CD45highCNS MPs is also recognized in AD that surround Aβ plaques. These transcriptionally and pathologically unique CD45highcells have unclear origin and undefined phagocytic characteristics. We have comprehensively validated rapid flow cytometric assays of bulk-phase and amyloid β fibril (fAβ) phagocytosis and applied these to study acutely isolated CNS MPs. Using these methods, we provide novel insights into differential abilities of CD11b+CD45lowand CD45highCNS MPs to phagocytose macroparticles and fAβ under normal, acute, and chronic neuroinflammatory states. CD45highCNS MPs also highly upregulate TREM2, CD11c, and several disease-associated microglia signature genes and have a higher phagocytic capacity for Aβ as compared to CD45lowmicroglia in the 5xFAD mouse model of AD that becomes more apparent with aging. Our data suggest an overall pro-phagocytic and protective role for CD11b+CD45highCNS MPs in neurodegeneration, which if promoted, could be beneficial. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 140 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 25% |
| Researcher | 24 | 17% |
| Student > Master | 16 | 11% |
| Student > Bachelor | 9 | 6% |
| Student > Doctoral Student | 6 | 4% |
| Other | 15 | 11% |
| Unknown | 35 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 30 | 21% |
| Biochemistry, Genetics and Molecular Biology | 23 | 16% |
| Agricultural and Biological Sciences | 14 | 10% |
| Immunology and Microbiology | 8 | 6% |
| Medicine and Dentistry | 7 | 5% |
| Other | 16 | 11% |
| Unknown | 42 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2018.
All research outputs
#3,276,019
of 25,382,440 outputs
Outputs from Frontiers in immunology
#3,533
of 31,537 outputs
Outputs of similar age
#65,238
of 346,135 outputs
Outputs of similar age from Frontiers in immunology
#115
of 692 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,537 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,135 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 692 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.