Title |
Molecular Determinants of Target Cell Recognition by Human γδ T Cells
|
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Published in |
Frontiers in immunology, April 2018
|
DOI | 10.3389/fimmu.2018.00929 |
Pubmed ID | |
Authors |
André E. Simões, Biagio Di Lorenzo, Bruno Silva-Santos |
Abstract |
The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising therapeutic strategies for cancer and infectious diseases. From a mechanistic standpoint, numerous studies have unveiled a remarkable flexibility of γδ T cells in employing their T cell receptor and/or NK cell receptors for target cell recognition, even if the relevant ligands often remain uncertain. Here, we review the accumulated knowledge on the diverse mechanisms of target cell recognition by γδ T cells, focusing on human γδ T cells, to provide an integrated perspective of their therapeutic potential in cancer and infectious diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 17% |
Unknown | 5 | 83% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 115 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 19 | 17% |
Researcher | 16 | 14% |
Student > Ph. D. Student | 14 | 12% |
Student > Bachelor | 10 | 9% |
Other | 6 | 5% |
Other | 10 | 9% |
Unknown | 40 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 27 | 23% |
Biochemistry, Genetics and Molecular Biology | 26 | 23% |
Agricultural and Biological Sciences | 9 | 8% |
Medicine and Dentistry | 7 | 6% |
Computer Science | 2 | 2% |
Other | 4 | 3% |
Unknown | 40 | 35% |