Title |
Autophagy and Its Interaction With Intracellular Bacterial Pathogens
|
---|---|
Published in |
Frontiers in immunology, May 2018
|
DOI | 10.3389/fimmu.2018.00935 |
Pubmed ID | |
Authors |
Mariana da Silva Siqueira, Renato de Moraes Ribeiro, Leonardo H. Travassos |
Abstract |
Cellular responses to stress can be defined by the overwhelming number of changes that cells go through upon contact with and stressful conditions such as infection and modifications in nutritional status. One of the main cellular responses to stress is autophagy. Much progress has been made in the understanding of the mechanisms involved in the induction of autophagy during infection by intracellular bacteria. This review aims to discuss recent findings on the role of autophagy as a cellular response to intracellular bacterial pathogens such as, Streptococcus pyogenes, Mycobacterium tuberculosis, Shigella flexneri, Salmonella typhimurium, Listeria monocytogenes, and Legionella pneumophila, how the autophagic machinery senses these bacteria directly or indirectly (through the detection of bacteria-induced nutritional stress), and how some of these bacterial pathogens manage to escape from autophagy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 2 | 29% |
Switzerland | 1 | 14% |
United Kingdom | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 133 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 28 | 21% |
Researcher | 20 | 15% |
Student > Bachelor | 13 | 10% |
Student > Doctoral Student | 9 | 7% |
Student > Master | 9 | 7% |
Other | 16 | 12% |
Unknown | 38 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 37 | 28% |
Immunology and Microbiology | 27 | 20% |
Agricultural and Biological Sciences | 12 | 9% |
Medicine and Dentistry | 9 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 5 | 4% |
Unknown | 41 | 31% |