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Dual Role of Toll-like Receptors in Human and Experimental Asthma Models

Overview of attention for article published in Frontiers in immunology, May 2018
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Title
Dual Role of Toll-like Receptors in Human and Experimental Asthma Models
Published in
Frontiers in immunology, May 2018
DOI 10.3389/fimmu.2018.01027
Pubmed ID
Authors

Amin Zakeri, Momtchilo Russo

Abstract

Asthma is a chronic airway inflammatory disease that is influenced by the interplay between genetic factors and exposure to environmental allergens, microbes, or microbial products where toll-like receptors (TLRs) play a pivotal role. TLRs recognize a wide range of microbial or endogenous molecules as well as airborne environmental allergens and act as adjuvants that influence positively or negatively allergic sensitization. TLRs are qualitatively and differentially expressed on hematopoietic and non-hematopoietic stromal or structural airway cells that when activated by TLRs agonists exert an immune-modulatory role in asthma development. Therefore, understanding mechanisms and pathways by which TLRs orchestrate asthma outcomes may offer new strategies to control the disease. Here, we aim to review and critically discuss the role of TLRs in human asthma and murine models of allergic airway inflammation, highlighting the complexity of TLRs function in development, exacerbation, or control of airway allergic inflammation.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 127 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 23 18%
Student > Ph. D. Student 16 13%
Student > Master 15 12%
Student > Doctoral Student 12 9%
Other 5 4%
Other 13 10%
Unknown 43 34%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 22 17%
Immunology and Microbiology 18 14%
Medicine and Dentistry 11 9%
Agricultural and Biological Sciences 6 5%
Pharmacology, Toxicology and Pharmaceutical Science 6 5%
Other 14 11%
Unknown 50 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2018.
All research outputs
#20,838,437
of 25,604,262 outputs
Outputs from Frontiers in immunology
#25,102
of 32,042 outputs
Outputs of similar age
#266,507
of 341,515 outputs
Outputs of similar age from Frontiers in immunology
#635
of 753 outputs
Altmetric has tracked 25,604,262 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 32,042 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,515 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 753 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.