Title |
Commensal Bacteria-Dependent CD8αβ+ T Cells in the Intestinal Epithelium Produce Antimicrobial Peptides
|
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Published in |
Frontiers in immunology, May 2018
|
DOI | 10.3389/fimmu.2018.01065 |
Pubmed ID | |
Authors |
Banru Chen, Xiang Ni, Rui Sun, Benhua Zeng, Hong Wei, Zhigang Tian, Haiming Wei |
Abstract |
The epithelium of the intestine functions as the primary "frontline" physical barrier for protection from enteric microbiota. Intraepithelial lymphocytes (IELs) distributed along the intestinal epithelium are predominantly CD8+ T cells, among which CD8αβ+ IELs are a large population. In this investigation, the proportion and absolute number of CD8αβ+ IELs decreased significantly in antibiotic-treated and germ-free mice. Moreover, the number of CD8αβ+ IELs was correlated closely with the load of commensal microbes, and induced by specific members of commensal bacteria. Microarray analysis revealed that CD8αβ+ IELs expressed a series of genes encoding potent antimicrobial peptides (AMPs), whereas CD8αβ+ splenocytes did not. The antimicrobial activity of CD8αβ+ IELs was confirmed by an antimicrobial-activity assay. In conclusion, microbicidal CD8αβ+ IELs are regulated by commensal bacteria which, in turn, secrete AMPs that have a vital role in maintaining the homeostasis of the small intestine. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 17% |
Researcher | 6 | 15% |
Student > Bachelor | 6 | 15% |
Student > Master | 4 | 10% |
Student > Doctoral Student | 3 | 7% |
Other | 7 | 17% |
Unknown | 8 | 20% |
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Biochemistry, Genetics and Molecular Biology | 5 | 12% |
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Medicine and Dentistry | 2 | 5% |
Other | 2 | 5% |
Unknown | 8 | 20% |