Title |
Effector T Helper Cell Subsets in Inflammatory Bowel Diseases
|
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Published in |
Frontiers in immunology, June 2018
|
DOI | 10.3389/fimmu.2018.01212 |
Pubmed ID | |
Authors |
Tanbeena Imam, Sungtae Park, Mark H. Kaplan, Matthew R. Olson |
Abstract |
The gastrointestinal tract is a site of high immune challenge, as it must maintain a delicate balance between tolerating luminal contents and generating an immune response toward pathogens. CD4+ T cells are key in mediating the host protective and homeostatic responses. Yet, CD4+ T cells are also known to be the main drivers of inflammatory bowel disease (IBD) when this balance is perturbed. Many subsets of CD4+ T cells have been identified as players in perpetuating chronic intestinal inflammation. Over the last few decades, understanding of how each subset of Th cells plays a role has dramatically increased. Simultaneously, this has allowed development of therapeutic innovation targeting specific molecules rather than broad immunosuppressive agents. Here, we review the emerging evidence of how each subset functions in promoting and sustaining the chronic inflammation that characterizes IBD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 25% |
Germany | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 294 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 52 | 18% |
Researcher | 45 | 15% |
Student > Bachelor | 31 | 11% |
Student > Master | 29 | 10% |
Student > Doctoral Student | 19 | 6% |
Other | 24 | 8% |
Unknown | 94 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 59 | 20% |
Immunology and Microbiology | 45 | 15% |
Medicine and Dentistry | 30 | 10% |
Agricultural and Biological Sciences | 25 | 9% |
Neuroscience | 5 | 2% |
Other | 29 | 10% |
Unknown | 101 | 34% |