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X Demographics
Mendeley readers
Attention Score in Context
| Title |
S100A8/A9 in Inflammation
|
|---|---|
| Published in |
Frontiers in immunology, June 2018
|
| DOI | 10.3389/fimmu.2018.01298 |
| Pubmed ID | |
| Authors |
Siwen Wang, Rui Song, Ziyi Wang, Zhaocheng Jing, Shaoxiong Wang, Jian Ma |
| Abstract |
S100A8 and S100A9 (also known as MRP8 and MRP14, respectively) are Ca2+ binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stability. S100A8/A9 is constitutively expressed in neutrophils and monocytes as a Ca2+ sensor, participating in cytoskeleton rearrangement and arachidonic acid metabolism. During inflammation, S100A8/A9 is released actively and exerts a critical role in modulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion. S100A8/A9 serves as a candidate biomarker for diagnosis and follow-up as well as a predictive indicator of therapeutic responses to inflammation-associated diseases. As blockade of S100A8/A9 activity using small-molecule inhibitors or antibodies improves pathological conditions in murine models, the heterodimer has potential as a therapeutic target. In this review, we provide a comprehensive and detailed overview of the distribution and biological functions of S100A8/A9 and highlight its application as a diagnostic and therapeutic target in inflammation-associated diseases. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 19% |
| Australia | 1 | 6% |
| Ireland | 1 | 6% |
| France | 1 | 6% |
| Austria | 1 | 6% |
| Egypt | 1 | 6% |
| Colombia | 1 | 6% |
| Switzerland | 1 | 6% |
| Unknown | 6 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 88% |
| Scientists | 1 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 681 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 681 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 120 | 18% |
| Student > Master | 81 | 12% |
| Researcher | 78 | 11% |
| Student > Bachelor | 71 | 10% |
| Student > Doctoral Student | 39 | 6% |
| Other | 77 | 11% |
| Unknown | 215 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 155 | 23% |
| Medicine and Dentistry | 87 | 13% |
| Immunology and Microbiology | 58 | 9% |
| Agricultural and Biological Sciences | 55 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 19 | 3% |
| Other | 63 | 9% |
| Unknown | 244 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2024.
All research outputs
#1,480,025
of 25,800,372 outputs
Outputs from Frontiers in immunology
#1,312
of 32,414 outputs
Outputs of similar age
#30,715
of 342,700 outputs
Outputs of similar age from Frontiers in immunology
#48
of 745 outputs
Altmetric has tracked 25,800,372 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,414 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,700 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 745 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.