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The Neutralizing Face of Hepatitis C Virus E2 Envelope Glycoprotein

Overview of attention for article published in Frontiers in immunology, June 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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Title
The Neutralizing Face of Hepatitis C Virus E2 Envelope Glycoprotein
Published in
Frontiers in immunology, June 2018
DOI 10.3389/fimmu.2018.01315
Pubmed ID
Authors

Netanel Tzarum, Ian A. Wilson, Mansun Law

Abstract

The high genetic variability of hepatitis C virus, together with the high level of glycosylation on the viral envelope proteins shielding potential neutralizing epitopes, pose a difficult challenge for vaccine development. An effective hepatitis C virus (HCV) vaccine must target conserved epitopes and the HCV E2 glycoprotein is the main target for such neutralizing antibodies (NAbs). Recent structural investigations highlight the presence of a highly conserved and accessible surface on E2 that is devoid of N-linked glycans and known as the E2 neutralizing face. This face is defined as a hydrophobic surface comprising the front layer (FL) and the CD81 binding loop (CD81bl) that overlap with the CD81 receptor binding site on E2. The neutralizing face consists of highly conserved residues for recognition by cross-NAbs, yet it appears to be high conformationally flexible, thereby presenting a moving target for NAbs. Three main overlapping neutralizing sites have been identified in the neutralizing face: antigenic site 412 (AS412), antigenic site 434 (AS434), and antigenic region 3 (AR3). Here, we review the structural analyses of these neutralizing sites, either as recombinant E2 or epitope-derived linear peptides in complex with bNAbs, to understand the functional and preferred conformations for neutralization, and for viral escape. Collectively, these studies provide a foundation and molecular templates to facilitate structure-based approaches for HCV vaccine development.

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X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 68 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 19%
Student > Bachelor 12 18%
Student > Ph. D. Student 10 15%
Student > Master 9 13%
Professor > Associate Professor 3 4%
Other 4 6%
Unknown 17 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 29%
Immunology and Microbiology 9 13%
Chemistry 6 9%
Agricultural and Biological Sciences 5 7%
Engineering 2 3%
Other 6 9%
Unknown 20 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2023.
All research outputs
#4,810,527
of 25,382,440 outputs
Outputs from Frontiers in immunology
#5,300
of 31,537 outputs
Outputs of similar age
#86,387
of 341,432 outputs
Outputs of similar age from Frontiers in immunology
#180
of 744 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,537 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,432 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 744 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.