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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Therapeutic Prospects of Extracellular Vesicles in Cancer Treatment
|
|---|---|
| Published in |
Frontiers in immunology, July 2018
|
| DOI | 10.3389/fimmu.2018.01534 |
| Pubmed ID | |
| Authors |
Daria S. Chulpanova, Kristina V. Kitaeva, Victoria James, Albert A. Rizvanov, Valeriya V. Solovyeva |
| Abstract |
Extracellular vesicles (EVs) are released by all cells within the tumor microenvironment, such as endothelial cells, tumor-associated fibroblasts, pericytes, and immune system cells. The EVs carry the cargo of parental cells formed of proteins and nucleic acids, which can convey cell-to-cell communication influencing the maintenance and spread of the malignant neoplasm, for example, promoting angiogenesis, tumor cell invasion, and immune escape. However, EVs can also suppress tumor progression, either by the direct influence of the protein and nucleic acid cargo of the EVs or via antigen presentation to immune cells as tumor-derived EVs carry on their surface some of the same antigens as the donor cells. Moreover, dendritic cell-derived EVs carry major histocompatibility complex class I and class II/peptide complexes and are able to prime other immune system cell types and activate an antitumor immune response. Given the relative longevity of vesicles within the circulation and their ability to cross blood-brain barriers, modification of these unique organelles offers the potential to create new biological-tools for cancer therapy. This review examines how modification of the EV cargo has the potential to target specific tumor mechanisms responsible for tumor formation and progression to develop new therapeutic strategies and to increase the efficacy of antitumor therapies. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| New Zealand | 2 | 18% |
| Austria | 1 | 9% |
| Australia | 1 | 9% |
| India | 1 | 9% |
| Japan | 1 | 9% |
| United Kingdom | 1 | 9% |
| Unknown | 4 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 55% |
| Scientists | 3 | 27% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 146 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 17% |
| Researcher | 22 | 15% |
| Student > Master | 20 | 14% |
| Student > Bachelor | 16 | 11% |
| Student > Doctoral Student | 7 | 5% |
| Other | 20 | 14% |
| Unknown | 36 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 42 | 29% |
| Medicine and Dentistry | 18 | 12% |
| Agricultural and Biological Sciences | 11 | 8% |
| Immunology and Microbiology | 6 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 21 | 14% |
| Unknown | 42 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2021.
All research outputs
#3,587,744
of 25,385,509 outputs
Outputs from Frontiers in immunology
#3,951
of 31,537 outputs
Outputs of similar age
#67,943
of 341,301 outputs
Outputs of similar age from Frontiers in immunology
#123
of 733 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,537 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,301 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 733 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.