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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4
|
|---|---|
| Published in |
Frontiers in immunology, July 2018
|
| DOI | 10.3389/fimmu.2018.01573 |
| Pubmed ID | |
| Authors |
Eva Guiducci, Christina Lemberg, Noëmi Küng, Elisabeth Schraner, Alexandre P. A. Theocharides, Salomé LeibundGut-Landmann |
| Abstract |
Neutrophils are the most abundant innate immune cells and the first line of defense against many pathogenic microbes, including the human fungal pathogen Candida albicans. Among the neutrophils' arsenal of effector functions, neutrophil extracellular traps (NETs) are thought to be of particular importance for trapping and killing the large fungal filaments by means of their web-like structures that consist of chromatin fibers decorated with proteolytic enzymes and host defense proteins. Peptidylarginine deiminase 4 (PAD4)-mediated citrullination of histones in activated neutrophils correlates with chromatin decondensation and extrusion and is widely accepted to act as an integral process of NET induction (NETosis). However, the requirement of PAD4-mediated histone citrullination for NET release during C. albicans infection remains unclear. In this study, we show that although PAD4-dependent neutrophil histone citrullination is readily induced by C. albicans, PAD4 is dispensable for NETosis in response to the fungus and other common NET-inducing stimuli. Moreover, PAD4 is not required for antifungal immunity during mucosal and systemic C. albicans infection. Our results demonstrate that PAD4 is dispensable for C. albicans-induced NETosis, and they highlight the limitations of using histone citrullination as a marker for NETs and PAD4-/- mice as a model of NET-deficiency. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 27% |
| Mexico | 2 | 18% |
| Canada | 1 | 9% |
| Malaysia | 1 | 9% |
| India | 1 | 9% |
| France | 1 | 9% |
| Switzerland | 1 | 9% |
| Unknown | 1 | 9% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 73% |
| Scientists | 3 | 27% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 75 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 13% |
| Researcher | 10 | 13% |
| Student > Ph. D. Student | 10 | 13% |
| Student > Bachelor | 7 | 9% |
| Student > Postgraduate | 5 | 7% |
| Other | 9 | 12% |
| Unknown | 24 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 15 | 20% |
| Biochemistry, Genetics and Molecular Biology | 14 | 19% |
| Medicine and Dentistry | 9 | 12% |
| Agricultural and Biological Sciences | 6 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 3 | 4% |
| Unknown | 26 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2018.
All research outputs
#7,000,448
of 25,385,509 outputs
Outputs from Frontiers in immunology
#7,613
of 31,537 outputs
Outputs of similar age
#112,227
of 339,673 outputs
Outputs of similar age from Frontiers in immunology
#227
of 706 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 31,537 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,673 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 706 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.