Title |
The Role of Efferocytosis in Autoimmune Diseases
|
---|---|
Published in |
Frontiers in immunology, July 2018
|
DOI | 10.3389/fimmu.2018.01645 |
Pubmed ID | |
Authors |
Fereshte Abdolmaleki, Najmeh Farahani, Seyed Mohammad Gheibi Hayat, Matteo Pirro, Vanessa Bianconi, George E. Barreto, Amirhossein Sahebkar |
Abstract |
Apoptosis happens continuously for millions of cells along with the active removal of apoptotic debris in order to maintain tissue homeostasis. In this respect, efferocytosis, i.e., the process of dead cell clearance, is orchestrated through cell exposure of a set of "find me," "eat me," and "tolerate me" signals facilitating the engulfment of dying cells through phagocytosis by macrophages and dendritic cells. The clearance of dead cells via phagocytes is of utmost importance to maintain the immune system tolerance to self-antigens. Accordingly, this biological activity prevents the release of autoantigens by dead cells, thus potentially suppressing the undesirable autoreactivity of immune cells and the appearance of inflammatory autoimmune disorders as systemic lupus erythematous and rheumatoid arthritis. In the present study, the apoptosis pathways and their immune regulation were reviewed. Moreover, efferocytosis process and its impairment in association with some autoimmune diseases were discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 114 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 25 | 22% |
Student > Doctoral Student | 11 | 10% |
Student > Master | 9 | 8% |
Student > Bachelor | 9 | 8% |
Researcher | 5 | 4% |
Other | 20 | 18% |
Unknown | 35 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 21 | 18% |
Biochemistry, Genetics and Molecular Biology | 13 | 11% |
Medicine and Dentistry | 9 | 8% |
Agricultural and Biological Sciences | 8 | 7% |
Engineering | 6 | 5% |
Other | 18 | 16% |
Unknown | 39 | 34% |