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Structurally Mapping Antibody Repertoires

Overview of attention for article published in Frontiers in immunology, July 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

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22 X users

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Title
Structurally Mapping Antibody Repertoires
Published in
Frontiers in immunology, July 2018
DOI 10.3389/fimmu.2018.01698
Pubmed ID
Authors

Konrad Krawczyk, Sebastian Kelm, Aleksandr Kovaltsuk, Jacob D Galson, Dominic Kelly, Johannes Trück, Cristian Regep, Jinwoo Leem, Wing K Wong, Jaroslaw Nowak, James Snowden, Michael Wright, Laura Starkie, Anthony Scott-Tucker, Jiye Shi, Charlotte M Deane

Abstract

Every human possesses millions of distinct antibodies. It is now possible to analyze this diversity via next-generation sequencing of immunoglobulin genes (Ig-seq). This technique produces large volume sequence snapshots of B-cell receptors that are indicative of the antibody repertoire. In this paper, we enrich these large-scale sequence datasets with structural information. Enriching a sequence with its structural data allows better approximation of many vital features, such as its binding site and specificity. Here, we describe the structural annotation of antibodies pipeline that maps the outputs of large Ig-seq experiments to known antibody structures. We demonstrate the viability of our protocol on five separate Ig-seq datasets covering ca. 35 m unique amino acid sequences from ca. 600 individuals. Despite the great theoretical diversity of antibodies, we find that the majority of sequences coming from such studies can be reliably mapped to an existing structure.

X Demographics

X Demographics

The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 98 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 29 30%
Student > Ph. D. Student 20 20%
Student > Master 9 9%
Student > Bachelor 7 7%
Other 6 6%
Other 9 9%
Unknown 18 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 32 33%
Agricultural and Biological Sciences 18 18%
Immunology and Microbiology 14 14%
Chemistry 5 5%
Engineering 2 2%
Other 6 6%
Unknown 21 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2019.
All research outputs
#3,142,690
of 25,552,933 outputs
Outputs from Frontiers in immunology
#3,317
of 31,950 outputs
Outputs of similar age
#59,580
of 341,297 outputs
Outputs of similar age from Frontiers in immunology
#88
of 636 outputs
Altmetric has tracked 25,552,933 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,950 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,297 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 636 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.