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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies
|
|---|---|
| Published in |
Frontiers in immunology, July 2018
|
| DOI | 10.3389/fimmu.2018.01740 |
| Pubmed ID | |
| Authors |
Hannah M. Knochelmann, Aubrey S. Smith, Connor J. Dwyer, Megan M. Wyatt, Shikhar Mehrotra, Chrystal M. Paulos |
| Abstract |
Genetic redirection of T lymphocytes with chimeric antigen receptors (CARs) has soared from treating cancers preclinically to FDA approval for hematologic malignancies and commercial-grade production scale in under 30 years. To date, solid tumors are less susceptible to CAR therapies and instead have been treated more successfully with immune checkpoint blockade or tumor-infiltrating lymphocyte therapy. Here, we discuss the current challenges in treating solid tumors with CAR T cells, and the obstacles within the host and tumor microenvironment hindering their efficacy. We present a novel three-pronged approach for enhancing the efficacy of CAR T cells whereby a single infusion product can synergize the power of an optimal CAR construct, a highly potent T cell subset, and rejuvenate the endogenous immune response to conquer therapeutically-resistant solid tumors. |
X Demographics
The data shown below were collected from the profiles of 62 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 16 | 26% |
| Spain | 5 | 8% |
| Mexico | 3 | 5% |
| Japan | 2 | 3% |
| Switzerland | 2 | 3% |
| France | 2 | 3% |
| United Kingdom | 2 | 3% |
| Georgia | 1 | 2% |
| Germany | 1 | 2% |
| Other | 8 | 13% |
| Unknown | 20 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 44 | 71% |
| Scientists | 13 | 21% |
| Practitioners (doctors, other healthcare professionals) | 4 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 260 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 260 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 45 | 17% |
| Researcher | 42 | 16% |
| Student > Bachelor | 31 | 12% |
| Student > Master | 22 | 8% |
| Student > Doctoral Student | 15 | 6% |
| Other | 30 | 12% |
| Unknown | 75 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 47 | 18% |
| Immunology and Microbiology | 34 | 13% |
| Medicine and Dentistry | 28 | 11% |
| Agricultural and Biological Sciences | 24 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 4% |
| Other | 31 | 12% |
| Unknown | 85 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 49. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2021.
All research outputs
#893,114
of 26,148,761 outputs
Outputs from Frontiers in immunology
#801
of 32,975 outputs
Outputs of similar age
#18,395
of 345,050 outputs
Outputs of similar age from Frontiers in immunology
#20
of 633 outputs
Altmetric has tracked 26,148,761 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,975 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,050 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 633 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.