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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity
|
|---|---|
| Published in |
Frontiers in immunology, February 2020
|
| DOI | 10.3389/fimmu.2020.00155 |
| Pubmed ID | |
| Authors |
Rodrigo Jiménez-Saiz, Varun C. Anipindi, Heather Galipeau, Yosef Ellenbogen, Roopali Chaudhary, Joshua F. Koenig, Melissa E. Gordon, Tina D. Walker, Talveer S. Mandur, Soumeya Abed, Alison Humbles, Derek K. Chu, Jonas Erjefält, Kjetil Ask, Elena F. Verdú, Manel Jordana |
| Abstract |
Eosinophils have emerged as multifaceted cells that contribute to tissue homeostasis. However, the impact of the microbiota on their frequency and function at mucosal sites remains unclear. Here, we investigated the role of the microbiota in the regulation of enteric eosinophils. We found that small intestinal (SI) eosinophilia was significantly greater in germ-free (GF) mice compared to specific pathogen free (SPF) controls. This was associated with changes in the production of enteric signals that regulate eosinophil attraction and survival, and was fully reversed by complex colonization. Additionally, SI eosinophils of GF mice exhibited more cytoplasmic protrusions and less granule content than SPF controls. Lastly, we generated a novel strain of eosinophil-deficient GF mice. These mice displayed intestinal fibrosis and were less prone to allergic sensitization as compared to GF controls. Overall, our study demonstrates that commensal microbes regulate intestinal eosinophil frequency and function, which impacts tissue repair and allergic sensitization to food antigens. These data support a critical interplay between the commensal microbiota and intestinal eosinophils in shaping homeostatic, innate, and adaptive immune processes in health and disease. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 11% |
| France | 1 | 5% |
| Japan | 1 | 5% |
| Italy | 1 | 5% |
| Canada | 1 | 5% |
| Unknown | 13 | 68% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 63% |
| Scientists | 4 | 21% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 16% |
| Student > Ph. D. Student | 9 | 14% |
| Researcher | 6 | 9% |
| Student > Doctoral Student | 6 | 9% |
| Student > Master | 5 | 8% |
| Other | 11 | 17% |
| Unknown | 17 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 18 | 28% |
| Medicine and Dentistry | 9 | 14% |
| Biochemistry, Genetics and Molecular Biology | 7 | 11% |
| Agricultural and Biological Sciences | 6 | 9% |
| Unspecified | 2 | 3% |
| Other | 3 | 5% |
| Unknown | 19 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2020.
All research outputs
#3,334,744
of 25,753,578 outputs
Outputs from Frontiers in immunology
#3,617
of 32,316 outputs
Outputs of similar age
#80,519
of 483,667 outputs
Outputs of similar age from Frontiers in immunology
#93
of 615 outputs
Altmetric has tracked 25,753,578 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,316 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 483,667 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 615 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.