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Genetic Influences on the Development of Fibrosis in Crohn’s Disease

Overview of attention for article published in Frontiers in Medicine, May 2016
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Title
Genetic Influences on the Development of Fibrosis in Crohn’s Disease
Published in
Frontiers in Medicine, May 2016
DOI 10.3389/fmed.2016.00024
Pubmed ID
Authors

Bram Verstockt, Isabelle Cleynen

Abstract

Fibrostenotic strictures are an important complication in patients with Crohn's disease (CD), very often necessitating surgery. This fibrotic process develops in a genetically susceptible individual and is influenced by an interplay with environmental, immunological, and disease-related factors. A deeper understanding of the genetic factors driving this fibrostenotic process might help to unravel the pathogenesis, and ultimately lead to development of new, anti-fibrotic therapy. Here, we review the genetic factors that have been associated with the development of fibrosis in patients with CD, as well as their potential pathophysiological mechanism(s). We also hypothesize on clinical implications, if any, and future research directions.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 28%
Student > Bachelor 8 22%
Researcher 5 14%
Student > Master 4 11%
Student > Postgraduate 2 6%
Other 3 8%
Unknown 4 11%
Readers by discipline Count As %
Medicine and Dentistry 16 44%
Biochemistry, Genetics and Molecular Biology 5 14%
Agricultural and Biological Sciences 3 8%
Immunology and Microbiology 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Other 2 6%
Unknown 6 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2016.
All research outputs
#18,456,836
of 22,869,263 outputs
Outputs from Frontiers in Medicine
#3,935
of 5,687 outputs
Outputs of similar age
#254,418
of 338,723 outputs
Outputs of similar age from Frontiers in Medicine
#6
of 13 outputs
Altmetric has tracked 22,869,263 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,687 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,723 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.