Title |
Focus on Nivolumab in NSCLC
|
---|---|
Published in |
Frontiers in Medicine, December 2016
|
DOI | 10.3389/fmed.2016.00067 |
Pubmed ID | |
Authors |
Diego L. Cortinovis, Stefania Canova, Marida Abbate, Francesca Colonese, Paolo Bidoli |
Abstract |
Immunotherapy is changing the treatment of non-small cell lung cancer (NSCLC). The PD-1 inhibitor nivolumab has demonstrated meaningful results in terms of efficacy with a good safety profile. The novel approach to treating NSCLC using immunotherapy still has unsolved questions and challenging issues. The main doubts regarding the optimal selection of the patient are the role of this drug in first line of treatment, the individualization of the correct methodology of radiologic assessment and efficacy analysis, the best management of immune-mediated adverse events, and how to overcome the immunoresistance. The aim of this review is to analyze literature data on nivolumab in lung cancer with a focus on critical aspects related to the drug in terms of safety, the use in clinical practice, and possible placement in the treatment algorithm. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Hong Kong | 1 | 20% |
France | 1 | 20% |
Switzerland | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 26% |
Student > Master | 6 | 16% |
Researcher | 5 | 13% |
Student > Doctoral Student | 3 | 8% |
Student > Ph. D. Student | 2 | 5% |
Other | 2 | 5% |
Unknown | 10 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 45% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Agricultural and Biological Sciences | 2 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 0 | 0% |
Unknown | 12 | 32% |