Title |
Pathophysiological Mechanisms in Sclerosing Skin Diseases
|
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Published in |
Frontiers in Medicine, August 2017
|
DOI | 10.3389/fmed.2017.00120 |
Pubmed ID | |
Authors |
Beate Eckes, Fang Wang, Pia Moinzadeh, Nicolas Hunzelmann, Thomas Krieg |
Abstract |
Sclerosing skin diseases represent a large number of distinct disease entities, which include systemic sclerosis, localized scleroderma, and scleredema adultorum. These pathologies have a common clinical appearance and share histological features. However, the specific interplay between cytokines and growth factors, which activate different mesenchymal cell populations and production of different extracellular matrix components, determines the biomechanical properties of the skin and the clinical features of each disease. A better understanding of the mechanisms underlying these events is prerequisite for developing novel targeted therapeutic approaches. |
X Demographics
Geographical breakdown
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 17% |
Other | 5 | 14% |
Student > Bachelor | 5 | 14% |
Student > Ph. D. Student | 4 | 11% |
Student > Postgraduate | 2 | 6% |
Other | 3 | 9% |
Unknown | 10 | 29% |
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Engineering | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Chemistry | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Other | 4 | 11% |
Unknown | 10 | 29% |