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Biochemical Pathways of Sarcopenia and Their Modulation by Physical Exercise: A Narrative Review

Overview of attention for article published in Frontiers in Medicine, October 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

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100 X users
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2 Facebook pages

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272 Mendeley
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Title
Biochemical Pathways of Sarcopenia and Their Modulation by Physical Exercise: A Narrative Review
Published in
Frontiers in Medicine, October 2017
DOI 10.3389/fmed.2017.00167
Pubmed ID
Authors

Mohammad Mosaferi Ziaaldini, Emanuele Marzetti, Anna Picca, Zsolt Murlasits

Abstract

Aging is a complex process characterized by progressive multisystem derangement predisposing individuals to increased risk of developing negative health outcomes. Sarcopenia is the age-related decline of muscle mass and function/strength and represents a highly prevalent correlate of aging. Several factors have been indicated to play a role in the onset and progression of sarcopenia; however, its pathophysiology is still unclear. Physical exercise is to date one of the few strategies able to improve muscle health in old age through multiple metabolic and transcriptional adaptations. Although the benefits of different exercise modalities on the function and structure of aged myocytes is acknowledged, the cellular and molecular mechanisms underlying such effects are not yet fully identified. Here, we briefly overview the current knowledge on the biochemical pathways associated with the onset and progression of sarcopenia. We subsequently describe the effects of exercise on relevant signaling pathways involved in sarcopenia pathophysiology.

X Demographics

X Demographics

The data shown below were collected from the profiles of 100 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 272 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 272 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 44 16%
Student > Ph. D. Student 30 11%
Student > Bachelor 30 11%
Researcher 25 9%
Student > Doctoral Student 20 7%
Other 38 14%
Unknown 85 31%
Readers by discipline Count As %
Medicine and Dentistry 54 20%
Biochemistry, Genetics and Molecular Biology 34 13%
Sports and Recreations 28 10%
Nursing and Health Professions 26 10%
Agricultural and Biological Sciences 14 5%
Other 23 8%
Unknown 93 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 60. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2021.
All research outputs
#721,246
of 25,808,886 outputs
Outputs from Frontiers in Medicine
#215
of 7,327 outputs
Outputs of similar age
#14,970
of 332,427 outputs
Outputs of similar age from Frontiers in Medicine
#4
of 65 outputs
Altmetric has tracked 25,808,886 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,327 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,427 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.