Title |
Disease Severity, Activity, Impact, and Control and How to Assess Them in Patients with Hereditary Angioedema
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Published in |
Frontiers in Medicine, December 2017
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DOI | 10.3389/fmed.2017.00212 |
Pubmed ID | |
Authors |
Anette Bygum, Paula Busse, Teresa Caballero, Marcus Maurer |
Abstract |
Hereditary angioedema (HAE) is a group of rare, potentially life-threatening, and frequently debilitating diseases characterized by recurrent, and often with an unpredictable onset, of swelling attacks. HAE is heterogeneous, with considerable differences between its subtypes, patients, and even within the same patient over time. During the past few years, several new on demand and prophylactic therapies have become available for HAE, allowing for individualized treatment. Therefore, to optimize HAE management, it is important to determine in all patients, the severity of their attacks, their disease activity, its therapeutic control, and its impact on their quality of life. In this manuscript, we review the existing tools to assess these aspects of HAE management, many of which are patient-reported outcome instruments. Also, we outline the current gaps of knowledge and what tools are still missing to allow for a comprehensive assessment of all patients with HAE including children. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 72 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 15% |
Other | 8 | 11% |
Student > Doctoral Student | 7 | 10% |
Student > Ph. D. Student | 6 | 8% |
Student > Bachelor | 4 | 6% |
Other | 12 | 17% |
Unknown | 24 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 36% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 10% |
Immunology and Microbiology | 3 | 4% |
Nursing and Health Professions | 2 | 3% |
Agricultural and Biological Sciences | 2 | 3% |
Other | 9 | 13% |
Unknown | 23 | 32% |