Title |
Toward the Relevance of Platelet Subpopulations for Transfusion Medicine
|
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Published in |
Frontiers in Medicine, February 2018
|
DOI | 10.3389/fmed.2018.00017 |
Pubmed ID | |
Authors |
Stefan Handtke, Leif Steil, Andreas Greinacher, Thomas Thiele |
Abstract |
Circulating platelets consist of subpopulations with different age, maturation state and size. In this review, we address the association between platelet size and platelet function and summarize the current knowledge on platelet subpopulations including reticulated platelets, procoagulant platelets and platelets exposing signals to mediate their clearance. Thereby, we emphasize the impact of platelet turnover as an important condition for platelet productionin vivo. Understanding of the features that characterize platelet subpopulations is very relevant for the methods of platelet concentrate production, which may enrich or deplete particular platelet subpopulations. Moreover, the concept of platelet size being associated with platelet function may be attractive for transfusion medicine as it holds the perspective to separate platelet subpopulations with specific functional capabilities. |
X Demographics
Geographical breakdown
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 24% |
Student > Master | 5 | 10% |
Researcher | 5 | 10% |
Other | 4 | 8% |
Student > Bachelor | 4 | 8% |
Other | 5 | 10% |
Unknown | 15 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 20% |
Biochemistry, Genetics and Molecular Biology | 9 | 18% |
Agricultural and Biological Sciences | 6 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Veterinary Science and Veterinary Medicine | 2 | 4% |
Other | 6 | 12% |
Unknown | 15 | 30% |