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Morphogenesis of the Infectious HIV-1 Virion

Overview of attention for article published in Frontiers in Microbiology, January 2011
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Title
Morphogenesis of the Infectious HIV-1 Virion
Published in
Frontiers in Microbiology, January 2011
DOI 10.3389/fmicb.2011.00242
Pubmed ID
Authors

Jun-ichi Sakuragi

Abstract

The virion of HIV-1 is spherical and viral glycoprotein spikes (gp120, gp41) protrude from its envelope. The characteristic cone-shaped core exists within the virion, caging the ribonucleoprotein (RNP) complex, which is comprised of viral RNA, nucleocapsid (NC), and viral enzymes. The HIV-1 virion is budded and released from the infected cell as an immature donut-shaped particle. During or immediately after release, viral protease (PR) is activated and subsequently processes the viral structural protein Gag. Through this maturation process, virions acquire infectivity, but its mechanism and transition of morphology largely remain unclear. Recent technological advances in experimental devices and techniques have made it possible to closely dissect the viral production site on the cell, the exterior - or even the interior - of an individual virion, and many new aspects on virion morphology and maturation. In this manuscript, I review the morphogenesis of HIV-1 virions. I focus on several studies, including some of our recent findings, which examined virion formation and/or maturation processes. The story of novel compound, which inhibits virion maturation, and the importance of maturation research are also discussed.

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Netherlands 1 1%
Unknown 97 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 17%
Student > Master 16 16%
Student > Bachelor 13 13%
Researcher 10 10%
Student > Postgraduate 6 6%
Other 8 8%
Unknown 29 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 28 28%
Agricultural and Biological Sciences 17 17%
Medicine and Dentistry 8 8%
Immunology and Microbiology 5 5%
Chemistry 4 4%
Other 7 7%
Unknown 30 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2023.
All research outputs
#20,744,283
of 25,483,400 outputs
Outputs from Frontiers in Microbiology
#21,765
of 29,433 outputs
Outputs of similar age
#171,346
of 190,964 outputs
Outputs of similar age from Frontiers in Microbiology
#92
of 126 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 29,433 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.