Title |
Measles Virus Hemagglutinin: Structural Insights into Cell Entry and Measles Vaccine
|
---|---|
Published in |
Frontiers in Microbiology, January 2011
|
DOI | 10.3389/fmicb.2011.00247 |
Pubmed ID | |
Authors |
Takao Hashiguchi, Katsumi Maenaka, Yusuke Yanagi |
Abstract |
Measles is one of the most contagious viral diseases, and remains a major cause of childhood morbidity and mortality worldwide. The measles virus (MV), a member of the family Paramyxoviridae, enters cells through a cellular receptor, the signaling lymphocyte activation molecule (SLAM), CD46 or nectin-4. Entry is mediated by two MV envelope glycoproteins, the hemagglutinin (H) and the fusion (F) protein. The H protein mediates receptor attachment, while the F protein causes membrane fusion. The interaction between the H and F proteins is essential to initiate the cell entry process. Recently determined crystal structures of the MV-H protein unbound and bound to SLAM or CD46 have provided insights into paramyxovirus entry and the effectiveness of measles vaccine. |
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