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Agent-Based Modeling Approach of Immune Defense Against Spores of Opportunistic Human Pathogenic Fungi

Overview of attention for article published in Frontiers in Microbiology, January 2012
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Title
Agent-Based Modeling Approach of Immune Defense Against Spores of Opportunistic Human Pathogenic Fungi
Published in
Frontiers in Microbiology, January 2012
DOI 10.3389/fmicb.2012.00129
Pubmed ID
Authors

Christian Tokarski, Sabine Hummert, Franziska Mech, Marc Thilo Figge, Sebastian Germerodt, Anja Schroeter, Stefan Schuster

Abstract

Opportunistic human pathogenic fungi like the ubiquitous fungus Aspergillus fumigatus are a major threat to immunocompromised patients. An impaired immune system renders the body vulnerable to invasive mycoses that often lead to the death of the patient. While the number of immunocompromised patients is rising with medical progress, the process, and dynamics of defense against invaded and ready to germinate fungal conidia are still insufficiently understood. Besides macrophages, neutrophil granulocytes form an important line of defense in that they clear conidia. Live imaging shows the interaction of those phagocytes and conidia as a dynamic process of touching, dragging, and phagocytosis. To unravel strategies of phagocytes on the hunt for conidia an agent-based modeling approach is used, implemented in NetLogo. Different modes of movement of phagocytes are tested regarding their clearing efficiency: random walk, short-term persistence in their recent direction, chemotaxis of chemokines excreted by conidia, and communication between phagocytes. While the short-term persistence hunting strategy turned out to be superior to the simple random walk, following a gradient of chemokines released by conidial agents is even better. The advantage of communication between neutrophilic agents showed a strong dependency on the spatial scale of the focused area and the distribution of the pathogens.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 3 5%
United States 2 3%
France 1 2%
Unknown 56 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 27%
Student > Ph. D. Student 13 21%
Student > Master 7 11%
Student > Doctoral Student 5 8%
Student > Bachelor 5 8%
Other 8 13%
Unknown 7 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 40%
Computer Science 9 15%
Mathematics 4 6%
Engineering 3 5%
Immunology and Microbiology 3 5%
Other 9 15%
Unknown 9 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2012.
All research outputs
#18,305,773
of 22,664,644 outputs
Outputs from Frontiers in Microbiology
#19,011
of 24,445 outputs
Outputs of similar age
#195,924
of 244,053 outputs
Outputs of similar age from Frontiers in Microbiology
#199
of 318 outputs
Altmetric has tracked 22,664,644 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,445 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,053 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 318 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.