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X Demographics
Mendeley readers
Attention Score in Context
| Title |
HBZ and its roles in HTLV-1 oncogenesis
|
|---|---|
| Published in |
Frontiers in Microbiology, January 2012
|
| DOI | 10.3389/fmicb.2012.00247 |
| Pubmed ID | |
| Authors |
Tiejun Zhao, Masao Matsuoka |
| Abstract |
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. However, HBZ is the only gene that remains intact and is consistently expressed in all ATL cases, while the tax gene is frequently inactivated by epigenetic modifications or deletion of the 5'LTR. HBZ gene promotes the proliferation of ATL cells through its mRNA form. Moreover, HBZ induces T-cell lymphoma and systemic inflammation in vivo. HBZ fulfills its functions mainly through regulating HTLV-1 5'LTR transcription and modulating a variety of cellular signaling pathways which are related with cell growth, immune response, and T-cell differentiation. Taken together, the multiple functions of HBZ render its predominant function in leukemogenesis of ATL. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Colombia | 1 | <1% |
| United States | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 102 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 31 | 29% |
| Student > Master | 14 | 13% |
| Researcher | 13 | 12% |
| Student > Ph. D. Student | 13 | 12% |
| Student > Postgraduate | 8 | 8% |
| Other | 8 | 8% |
| Unknown | 19 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 28% |
| Medicine and Dentistry | 22 | 21% |
| Biochemistry, Genetics and Molecular Biology | 15 | 14% |
| Immunology and Microbiology | 14 | 13% |
| Unspecified | 1 | <1% |
| Other | 3 | 3% |
| Unknown | 21 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2012.
All research outputs
#18,310,549
of 22,671,366 outputs
Outputs from Frontiers in Microbiology
#19,018
of 24,456 outputs
Outputs of similar age
#195,955
of 244,075 outputs
Outputs of similar age from Frontiers in Microbiology
#199
of 318 outputs
Altmetric has tracked 22,671,366 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,456 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,075 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 318 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.