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X Demographics
Mendeley readers
Attention Score in Context
| Title |
It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug
|
|---|---|
| Published in |
Frontiers in Microbiology, January 2012
|
| DOI | 10.3389/fmicb.2012.00286 |
| Pubmed ID | |
| Authors |
Ana C. Mesa-Arango, Liliana Scorzoni, Oscar Zaragoza |
| Abstract |
"Amphotericin B acts through pore formation at the cell membrane after binding to ergosterol" is an accepted dogma about the action mechanism of this antifungal, and this sentence is widely found in the literature. But after 60 years of investigation, the action mechanism of Amphotericin B is not fully elucidated. Amphotericin B is a polyene substance that is one of the most effective drugs for the treatment of fungal and parasite infections. As stated above, the first mechanism of action described was pore formation after binding to the ergosterol present in the membrane. But it has also been demonstrated that AmB induces oxidative damage in the cells. Moreover, amphotericin B modulates the immune system, and this activity has been related to the protective effect of the molecule, but also to its toxicity in the host. This review tries to provide a general overview of the main aspects of this molecule, and highlight the multiple effects that this molecule has on both the fungal and host cells. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Switzerland | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 365 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | <1% |
| Denmark | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 361 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 68 | 19% |
| Student > Ph. D. Student | 53 | 15% |
| Student > Master | 46 | 13% |
| Researcher | 32 | 9% |
| Student > Doctoral Student | 16 | 4% |
| Other | 50 | 14% |
| Unknown | 100 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 62 | 17% |
| Biochemistry, Genetics and Molecular Biology | 61 | 17% |
| Medicine and Dentistry | 32 | 9% |
| Immunology and Microbiology | 32 | 9% |
| Chemistry | 22 | 6% |
| Other | 40 | 11% |
| Unknown | 116 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2023.
All research outputs
#6,501,290
of 25,773,273 outputs
Outputs from Frontiers in Microbiology
#5,825
of 29,792 outputs
Outputs of similar age
#52,593
of 251,867 outputs
Outputs of similar age from Frontiers in Microbiology
#53
of 319 outputs
Altmetric has tracked 25,773,273 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 29,792 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,867 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 319 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.