Title |
MicroRNAs in HIV-1 infection: an integration of viral and cellular interaction at the genomic level
|
---|---|
Published in |
Frontiers in Microbiology, January 2012
|
DOI | 10.3389/fmicb.2012.00306 |
Pubmed ID | |
Authors |
Neil H. Tan Gana, Tomohiro Onuki, Ann Florence B. Victoriano, Takashi Okamoto |
Abstract |
The microRNA pathways govern complex interactions of the host and virus at the transcripts level that regulate cellular responses, viral replication and viral pathogenesis. As a group of single-stranded short non-coding ribonucleotides (ncRNAs), the microRNAs complement their messenger RNA (mRNA) targets to effect post-transcriptional or translational gene silencing. Previous studies showed the ability of human immunodeficiency virus 1 (HIV-1) to encode microRNAs which modify cellular defence mechanisms thus creating an environment favorable for viral invasion and replication. In corollary, cellular microRNAs were linked to the alteration of HIV-1 infection at different stages of replication and latency. As evidences further establish the regulatory involvement of both cellular and viral microRNA in HIV-1-host interactions, there is a necessity to organize this information. This paper would present current and emerging knowledge on these multi-dimensional interactions that may facilitate the design of microRNAs as effective antiretroviral reagents. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 33% |
United States | 1 | 33% |
Australia | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 34% |
Student > Bachelor | 5 | 13% |
Researcher | 4 | 11% |
Student > Doctoral Student | 3 | 8% |
Other | 2 | 5% |
Other | 4 | 11% |
Unknown | 7 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 32% |
Biochemistry, Genetics and Molecular Biology | 7 | 18% |
Immunology and Microbiology | 5 | 13% |
Medicine and Dentistry | 2 | 5% |
Computer Science | 1 | 3% |
Other | 1 | 3% |
Unknown | 10 | 26% |