Title |
Concentration-dependent activity of antibiotics in natural environments
|
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Published in |
Frontiers in Microbiology, January 2013
|
DOI | 10.3389/fmicb.2013.00020 |
Pubmed ID | |
Authors |
Steve P. Bernier, Michael G. Surette |
Abstract |
Bacterial responses to antibiotics are concentration-dependent. At high concentrations, antibiotics exhibit antimicrobial activities on susceptible cells, while subinhibitory concentrations induce diverse biological responses in bacteria. At non-lethal concentrations, bacteria may sense antibiotics as extracellular chemicals to trigger different cellular responses, which may include an altered antibiotic resistance/tolerance profile. In natural settings, microbes are typically in polymicrobial communities and antibiotic-mediated interactions between species may play a significant role in bacterial community structure and function. However, these aspects have not yet fully been explored at the community level. Here we discuss the different types of interactions mediated by antibiotics and non-antibiotic metabolites as a function of their concentrations and speculate on how these may amplify the overall antibiotic resistance/tolerance and the spread of antibiotic resistance determinants in a context of polymicrobial community. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 2 | 50% |
Switzerland | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 7 | 1% |
Estonia | 2 | <1% |
Sweden | 1 | <1% |
Israel | 1 | <1% |
Denmark | 1 | <1% |
Germany | 1 | <1% |
Canada | 1 | <1% |
Poland | 1 | <1% |
Unknown | 466 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 100 | 21% |
Researcher | 74 | 15% |
Student > Bachelor | 64 | 13% |
Student > Master | 40 | 8% |
Student > Doctoral Student | 19 | 4% |
Other | 63 | 13% |
Unknown | 121 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 140 | 29% |
Biochemistry, Genetics and Molecular Biology | 67 | 14% |
Immunology and Microbiology | 35 | 7% |
Environmental Science | 27 | 6% |
Medicine and Dentistry | 16 | 3% |
Other | 58 | 12% |
Unknown | 138 | 29% |