Title |
Microbial Production of Isoprenoids Enabled by Synthetic Biology
|
---|---|
Published in |
Frontiers in Microbiology, January 2013
|
DOI | 10.3389/fmicb.2013.00075 |
Pubmed ID | |
Authors |
Cheryl M. Immethun, Allison G. Hoynes-O’Connor, Andrea Balassy, Tae Seok Moon |
Abstract |
Microorganisms transform inexpensive carbon sources into highly functionalized compounds without toxic by-product generation or significant energy consumption. By redesigning the natural biosynthetic pathways in an industrially suited host, microbial cell factories can produce complex compounds for a variety of industries. Isoprenoids include many medically important compounds such as antioxidants and anticancer and antimalarial drugs, all of which have been produced microbially. While a biosynthetic pathway could be simply transferred to the production host, the titers would become economically feasible when it is rationally designed, built, and optimized through synthetic biology tools. These tools have been implemented by a number of research groups, with new tools pledging further improvements in yields and expansion to new medically relevant compounds. This review focuses on the microbial production of isoprenoids for the health industry and the advancements though synthetic biology. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 22% |
France | 2 | 22% |
Switzerland | 2 | 22% |
Aruba | 1 | 11% |
Unknown | 2 | 22% |
Demographic breakdown
Type | Count | As % |
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Scientists | 5 | 56% |
Members of the public | 4 | 44% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 2% |
France | 1 | <1% |
India | 1 | <1% |
New Zealand | 1 | <1% |
United Kingdom | 1 | <1% |
China | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Unknown | 174 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 41 | 22% |
Researcher | 36 | 20% |
Student > Master | 25 | 14% |
Student > Bachelor | 21 | 11% |
Other | 10 | 5% |
Other | 24 | 13% |
Unknown | 26 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 67 | 37% |
Biochemistry, Genetics and Molecular Biology | 41 | 22% |
Engineering | 15 | 8% |
Chemistry | 8 | 4% |
Chemical Engineering | 5 | 3% |
Other | 18 | 10% |
Unknown | 29 | 16% |