Title |
Antibiotic growth promoters enhance animal production by targeting intestinal bile salt hydrolase and its producers
|
---|---|
Published in |
Frontiers in Microbiology, January 2014
|
DOI | 10.3389/fmicb.2014.00033 |
Pubmed ID | |
Authors |
Jun Lin |
Abstract |
The growth-promoting effect of antibiotic growth promoters (AGPs) was correlated with the decreased activity of bile salt hydrolase (BSH), an intestinal bacteria-produced enzyme that exerts negative impact on host fat digestion and utilization. Consistent with this finding, independent chicken studies have demonstrated that AGP usage significantly reduced population of Lactobacillus species, the major BSH-producers in the intestine. Recent finding also demonstrated that some AGPs, such as tetracycline and roxarsone, display direct inhibitory effect on BSH activity. Therefore, BSH is a promising microbiome target for developing novel alternatives to AGPs. Specifically, dietary supplementation of BSH inhibitor may promote host lipid metabolism and energy harvest, consequently enhancing feed efficiency and body weight gain in food animals. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 163 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 29 | 18% |
Researcher | 21 | 13% |
Student > Master | 18 | 11% |
Student > Bachelor | 17 | 10% |
Student > Doctoral Student | 10 | 6% |
Other | 36 | 22% |
Unknown | 32 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 60 | 37% |
Veterinary Science and Veterinary Medicine | 17 | 10% |
Medicine and Dentistry | 15 | 9% |
Biochemistry, Genetics and Molecular Biology | 8 | 5% |
Immunology and Microbiology | 5 | 3% |
Other | 16 | 10% |
Unknown | 42 | 26% |