Title |
The lack of a big picture in tuberculosis: the clinical point of view, the problems of experimental modeling and immunomodulation. The factors we should consider when designing novel treatment strategies
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Published in |
Frontiers in Microbiology, January 2014
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DOI | 10.3389/fmicb.2014.00055 |
Pubmed ID | |
Authors |
Cristina Vilaplana, Pere-Joan Cardona |
Abstract |
This short review explores the large gap between clinical issues and basic science, and suggests why tuberculosis research should focus on redirect the immune system and not only on eradicating Mycobacterium tuberculosis bacillus. Along the manuscript, several concepts involved in human tuberculosis are explored in order to understand the big picture, including infection and disease dynamics, animal modeling, liquefaction, inflammation and immunomodulation. Scientists should take into account all these factors in order to answer questions with clinical relevance. Moreover, the inclusion of the concept of a strong inflammatory response being required in order to develop cavitary tuberculosis disease opens a new field for developing new therapeutic and prophylactic tools in which destruction of the bacilli may not necessarily be the final goal. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 20% |
Netherlands | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 2% |
Denmark | 1 | 2% |
Canada | 1 | 2% |
Unknown | 60 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 19% |
Student > Ph. D. Student | 9 | 14% |
Student > Bachelor | 8 | 13% |
Student > Master | 7 | 11% |
Professor | 4 | 6% |
Other | 9 | 14% |
Unknown | 14 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 24% |
Medicine and Dentistry | 12 | 19% |
Immunology and Microbiology | 7 | 11% |
Engineering | 3 | 5% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Other | 7 | 11% |
Unknown | 17 | 27% |