Title |
Impact of the gut microbiota on the development of obesity and type 2 diabetes mellitus
|
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Published in |
Frontiers in Microbiology, April 2014
|
DOI | 10.3389/fmicb.2014.00190 |
Pubmed ID | |
Authors |
Isabel Moreno-Indias, Fernando Cardona, Francisco J. Tinahones, María Isabel Queipo-Ortuño |
Abstract |
Obesity and its associated disorders are a major public health concern. Although obesity has been mainly related with perturbations of the balance between food intake and energy expenditure, other factors must nevertheless be considered. Recent insight suggests that an altered composition and diversity of gut microbiota could play an important role in the development of metabolic disorders. This review discusses research aimed at understanding the role of gut microbiota in the pathogenesis of obesity and type 2 diabetes mellitus (TDM2). The establishment of gut microbiota is dependent on the type of birth. With effect from this point, gut microbiota remain quite stable, although changes take place between birth and adulthood due to external influences, such as diet, disease and environment. Understand these changes is important to predict diseases and develop therapies. A new theory suggests that gut microbiota contribute to the regulation of energy homeostasis, provoking the development of an impairment in energy homeostasis and causing metabolic diseases, such as insulin resistance or TDM2. The metabolic endotoxemia, modifications in the secretion of incretins and butyrate production might explain the influence of the microbiota in these diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 3 | 43% |
United States | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 86% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | <1% |
Malaysia | 1 | <1% |
Chile | 1 | <1% |
Ghana | 1 | <1% |
Brazil | 1 | <1% |
Netherlands | 1 | <1% |
India | 1 | <1% |
Israel | 1 | <1% |
United Kingdom | 1 | <1% |
Other | 1 | <1% |
Unknown | 617 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 108 | 17% |
Student > Bachelor | 96 | 15% |
Student > Ph. D. Student | 89 | 14% |
Researcher | 79 | 13% |
Student > Doctoral Student | 31 | 5% |
Other | 116 | 18% |
Unknown | 109 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 135 | 21% |
Medicine and Dentistry | 117 | 19% |
Biochemistry, Genetics and Molecular Biology | 95 | 15% |
Nursing and Health Professions | 31 | 5% |
Immunology and Microbiology | 25 | 4% |
Other | 91 | 14% |
Unknown | 134 | 21% |