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A comprehensive analysis of the Omp85/TpsB protein superfamily structural diversity, taxonomic occurrence, and evolution

Overview of attention for article published in Frontiers in Microbiology, July 2014
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Title
A comprehensive analysis of the Omp85/TpsB protein superfamily structural diversity, taxonomic occurrence, and evolution
Published in
Frontiers in Microbiology, July 2014
DOI 10.3389/fmicb.2014.00370
Pubmed ID
Authors

Eva Heinz, Trevor Lithgow

Abstract

Members of the Omp85/TpsB protein superfamily are ubiquitously distributed in Gram-negative bacteria, and function in protein translocation (e.g., FhaC) or the assembly of outer membrane proteins (e.g., BamA). Several recent findings are suggestive of a further level of variation in the superfamily, including the identification of the novel membrane protein assembly factor TamA and protein translocase PlpD. To investigate the diversity and the causal evolutionary events, we undertook a comprehensive comparative sequence analysis of the Omp85/TpsB proteins. A total of 10 protein subfamilies were apparent, distinguished in their domain structure and sequence signatures. In addition to the proteins FhaC, BamA, and TamA, for which structural and functional information is available, are families of proteins with so far undescribed domain architectures linked to the Omp85 β-barrel domain. This study brings a classification structure to a dynamic protein superfamily of high interest given its essential function for Gram-negative bacteria as well as its diverse domain architecture, and we discuss several scenarios of putative functions of these so far undescribed proteins.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 55 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 29%
Researcher 9 16%
Student > Bachelor 5 9%
Student > Doctoral Student 4 7%
Student > Master 3 5%
Other 3 5%
Unknown 15 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 31%
Biochemistry, Genetics and Molecular Biology 16 29%
Immunology and Microbiology 3 5%
Unspecified 1 2%
Environmental Science 1 2%
Other 1 2%
Unknown 16 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2022.
All research outputs
#15,030,198
of 23,122,481 outputs
Outputs from Frontiers in Microbiology
#14,035
of 25,321 outputs
Outputs of similar age
#126,853
of 229,412 outputs
Outputs of similar age from Frontiers in Microbiology
#104
of 178 outputs
Altmetric has tracked 23,122,481 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 25,321 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,412 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 178 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.