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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Modulation of the unfolded protein response by the human hepatitis B virus
|
|---|---|
| Published in |
Frontiers in Microbiology, August 2014
|
| DOI | 10.3389/fmicb.2014.00433 |
| Pubmed ID | |
| Authors |
Catalin Lazar, Mihaela Uta, Norica Branza-Nichita |
| Abstract |
During productive viral infection the host cell is confronted with synthesis of a vast amount of viral proteins which must be folded, quality controlled, assembled and secreted, perturbing the normal function of the endoplasmic reticulum (ER). To counteract the ER stress, cells activate specific signaling pathways, designated as the unfolded proteins response (UPR), which essentially increase their folding capacity, arrest protein translation, and degrade the excess of misfolded proteins. This cellular defense mechanism may, in turn, affect significantly the virus life-cycle. This review highlights the current understanding of the mechanisms of the ER stress activation by Human Hepatitis B virus (HBV), a deadly pathogen affecting more than 350 million people worldwide. Further discussion addresses the latest discoveries regarding the adaptive strategies developed by HBV to manipulate the UPR for its own benefits, the controversies in the field and future perspectives. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Switzerland | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 41 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 26% |
| Student > Ph. D. Student | 9 | 21% |
| Student > Doctoral Student | 5 | 12% |
| Other | 4 | 9% |
| Student > Master | 4 | 9% |
| Other | 7 | 16% |
| Unknown | 3 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 42% |
| Medicine and Dentistry | 9 | 21% |
| Biochemistry, Genetics and Molecular Biology | 7 | 16% |
| Immunology and Microbiology | 3 | 7% |
| Linguistics | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 4 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2014.
All research outputs
#14,136,447
of 22,760,687 outputs
Outputs from Frontiers in Microbiology
#12,164
of 24,645 outputs
Outputs of similar age
#120,483
of 235,512 outputs
Outputs of similar age from Frontiers in Microbiology
#89
of 163 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,645 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,512 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 163 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.