Title |
Insights into novel antimicrobial compounds and antibiotic resistance genes from soil metagenomes
|
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Published in |
Frontiers in Microbiology, September 2014
|
DOI | 10.3389/fmicb.2014.00489 |
Pubmed ID | |
Authors |
Alinne P. de Castro, Gabriel da R. Fernandes, Octávio L. Franco |
Abstract |
In recent years a major worldwide problem has arisen with regard to infectious diseases caused by resistant bacteria. Resistant pathogens are related to high mortality and also to enormous healthcare costs. In this field, cultured microorganisms have been commonly focused in attempts to isolate antibiotic resistance genes or to identify antimicrobial compounds. Although this strategy has been successful in many cases, most of the microbial diversity and related antimicrobial molecules have been completely lost. As an alternative, metagenomics has been used as a reliable approach to reveal the prospective reservoir of antimicrobial compounds and antibiotic resistance genes in the uncultured microbial community that inhabits a number of environments. In this context, this review will focus on resistance genes as well as on novel antibiotics revealed by a metagenomics approach from the soil environment. Biotechnology prospects are also discussed, opening new frontiers for antibiotic development. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 45% |
United Kingdom | 1 | 9% |
Unknown | 5 | 45% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 73% |
Scientists | 3 | 27% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 2% |
Brazil | 3 | 2% |
Portugal | 2 | 1% |
United Kingdom | 2 | 1% |
Denmark | 2 | 1% |
Estonia | 1 | <1% |
Mexico | 1 | <1% |
Unknown | 174 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 38 | 20% |
Student > Ph. D. Student | 31 | 16% |
Student > Bachelor | 28 | 15% |
Student > Master | 24 | 13% |
Other | 9 | 5% |
Other | 29 | 15% |
Unknown | 30 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 79 | 42% |
Biochemistry, Genetics and Molecular Biology | 33 | 17% |
Immunology and Microbiology | 10 | 5% |
Environmental Science | 8 | 4% |
Medicine and Dentistry | 7 | 4% |
Other | 22 | 12% |
Unknown | 30 | 16% |