Title |
A new strategy to fight antimicrobial resistance: the revival of old antibiotics
|
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Published in |
Frontiers in Microbiology, October 2014
|
DOI | 10.3389/fmicb.2014.00551 |
Pubmed ID | |
Authors |
Nadim Cassir, Jean-Marc Rolain, Philippe Brouqui |
Abstract |
The increasing prevalence of hospital and community-acquired infections caused by multidrug-resistant (MDR) bacterial pathogens is limiting the options for effective antibiotic therapy. Moreover, this alarming spread of antimicrobial resistance has not been paralleled by the development of novel antimicrobials. Resistance to the scarce new antibiotics is also emerging. In this context, the rational use of older antibiotics could represent an alternative to the treatment of MDR bacterial pathogens. It would help to optimize the armamentarium of antibiotics in the way to preserve new antibiotics and avoid the prescription of molecules known to favor the spread of resistance (i.e., quinolones). Furthermore, in a global economical perspective, this could represent a useful public health orientation knowing that several of these cheapest "forgotten" antibiotics are not available in many countries. We will review here the successful treatment of MDR bacterial infections with the use of old antibiotics and discuss their place in current practice. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 12% |
Spain | 2 | 8% |
Chile | 1 | 4% |
Ireland | 1 | 4% |
South Africa | 1 | 4% |
United States | 1 | 4% |
Venezuela, Bolivarian Republic of | 1 | 4% |
Switzerland | 1 | 4% |
France | 1 | 4% |
Other | 0 | 0% |
Unknown | 13 | 52% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 14 | 56% |
Scientists | 7 | 28% |
Practitioners (doctors, other healthcare professionals) | 3 | 12% |
Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 4 | <1% |
India | 3 | <1% |
United Kingdom | 3 | <1% |
Canada | 2 | <1% |
France | 1 | <1% |
Portugal | 1 | <1% |
Netherlands | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Other | 0 | 0% |
Unknown | 457 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 92 | 19% |
Student > Master | 69 | 15% |
Student > Bachelor | 60 | 13% |
Researcher | 45 | 9% |
Student > Doctoral Student | 31 | 7% |
Other | 85 | 18% |
Unknown | 92 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 72 | 15% |
Agricultural and Biological Sciences | 71 | 15% |
Medicine and Dentistry | 71 | 15% |
Immunology and Microbiology | 39 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 35 | 7% |
Other | 74 | 16% |
Unknown | 112 | 24% |