Title |
Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection
|
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Published in |
Frontiers in Microbiology, December 2014
|
DOI | 10.3389/fmicb.2014.00686 |
Pubmed ID | |
Authors |
Susanne H. Hodgson, Elizabeth Juma, Amina Salim, Charles Magiri, Domtila Kimani, Daniel Njenga, Alfred Muia, Andrew O. Cole, Caroline Ogwang, Ken Awuondo, Brett Lowe, Marianne Munene, Peter F. Billingsley, Eric R. James, Anusha Gunasekera, B. Kim L. Sim, Patricia Njuguna, Thomas W. Rampling, Adam Richman, Yonas Abebe, Gathoni Kamuyu, Michelle Muthui, Sean C. Elias, Sassy Molyneux, Stephen Gerry, Alex Macharia, Thomas N. Williams, Peter C. Bull, Adrian V. S. Hill, Faith H. Osier, Simon J. Draper, Philip Bejon, Stephen L. Hoffman, Bernhards Ogutu, Kevin Marsh |
Abstract |
Controlled human malaria infection (CHMI) studies are a vital tool to accelerate vaccine and drug development. As CHMI trials are performed in a controlled environment, they allow unprecedented, detailed evaluation of parasite growth dynamics (PGD) and immunological responses. However, CHMI studies have not been routinely performed in malaria-endemic countries or used to investigate mechanisms of naturally-acquired immunity (NAI) to Plasmodium falciparum. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Kenya | 2 | 2% |
Tanzania, United Republic of | 1 | <1% |
Portugal | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Unknown | 110 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 19% |
Student > Ph. D. Student | 17 | 15% |
Student > Master | 16 | 14% |
Other | 10 | 9% |
Student > Bachelor | 6 | 5% |
Other | 15 | 13% |
Unknown | 30 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 20% |
Immunology and Microbiology | 15 | 13% |
Agricultural and Biological Sciences | 15 | 13% |
Biochemistry, Genetics and Molecular Biology | 7 | 6% |
Nursing and Health Professions | 7 | 6% |
Other | 17 | 15% |
Unknown | 32 | 28% |