Title |
Vaccination against Q fever for biodefense and public health indications
|
---|---|
Published in |
Frontiers in Microbiology, December 2014
|
DOI | 10.3389/fmicb.2014.00726 |
Pubmed ID | |
Authors |
Sara Ruiz, Daniel N. Wolfe |
Abstract |
Coxiella burnetii is the etiological agent of Q fever, a disease that is often spread to humans via inhalational exposure to the bacteria from contaminated agricultural sources. Outbreaks have been observed all over the world with larger foci generating interest in vaccination programs, most notably in Australia and the Netherlands. Importantly, exposure rates among military personnel deployed to the Middle East can be relatively high as measured by seroconversion to C. burnetii-specific antibodies. Q fever has been of interest to the biodefense community over the years due to its low infectious dose and environmental stability. Recent advances in cell-free growth and genetics of C. burnetii also make this organism easier to culture and manipulate. While there is a vaccine that is licensed for use in Australia, the combination of biodefense- and public health-related issues associated with Q fever warrant the development of a safer and more effective vaccine against this disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 3 | 60% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Sweden | 1 | 2% |
Australia | 1 | 2% |
Unknown | 56 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 15 | 26% |
Researcher | 9 | 16% |
Student > Master | 8 | 14% |
Student > Bachelor | 6 | 10% |
Student > Doctoral Student | 3 | 5% |
Other | 6 | 10% |
Unknown | 11 | 19% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 12 | 21% |
Veterinary Science and Veterinary Medicine | 10 | 17% |
Biochemistry, Genetics and Molecular Biology | 6 | 10% |
Medicine and Dentistry | 6 | 10% |
Immunology and Microbiology | 4 | 7% |
Other | 7 | 12% |
Unknown | 13 | 22% |